Gene expression RNA interference in adult mice
RNA interference is an evolutionarily conserved surveillance mechanism that responds to double-stranded RNA by sequence-specific silencing of homologous genes. Here we show that transgene expression can be suppressed in adult mice by synthetic small interfering RNAs and by small-hairpin RNAs transcr...
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| Published in | Nature (London) Vol. 418; no. 6893; pp. 38 - 39 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group
04.07.2002
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| Subjects | |
| Online Access | Get full text |
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| Abstract | RNA interference is an evolutionarily conserved surveillance mechanism that responds to double-stranded RNA by sequence-specific silencing of homologous genes. Here we show that transgene expression can be suppressed in adult mice by synthetic small interfering RNAs and by small-hairpin RNAs transcribed in vivo from DNA templates. We also show the therapeutic potential of this technique by demonstrating effective targeting of a sequence from hepatitis C virus by RNA interference in vivo. |
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| AbstractList | RNA interference is an evolutionarily conserved surveillance mechanism that responds to double-stranded RNA by sequence-specific silencing of homologous genes. Here we show that transgene expression can be suppressed in adult mice by synthetic small interfering RNAs and by small-hairpin RNAs transcribed in vivo from DNA templates. We also show the therapeutic potential of this technique by demonstrating effective targeting of a sequence from hepatitis C virus by RNA interference in vivo. |
| Audience | Academic |
| Author | Meuse, Leonard Pham, Thu-Thao T McCaffrey, Anton P Hannon, Gregory J Kay, Mark A Conklin, Douglas S |
| Author_xml | – sequence: 1 givenname: Mark A surname: Kay fullname: Kay, Mark A organization: Departments of Pediatrics and Genetics, Stanford University School of Medicine – sequence: 2 givenname: Anton P surname: McCaffrey fullname: McCaffrey, Anton P organization: Departments of Pediatrics and Genetics, Stanford University School of Medicine – sequence: 3 givenname: Leonard surname: Meuse fullname: Meuse, Leonard organization: Departments of Pediatrics and Genetics, Stanford University School of Medicine – sequence: 4 givenname: Thu-Thao T surname: Pham fullname: Pham, Thu-Thao T organization: Departments of Pediatrics and Genetics, Stanford University School of Medicine – sequence: 5 givenname: Douglas S surname: Conklin fullname: Conklin, Douglas S organization: Cold Spring Harbor Laboratory – sequence: 6 givenname: Gregory J surname: Hannon fullname: Hannon, Gregory J organization: Cold Spring Harbor Laboratory |
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| Copyright | COPYRIGHT 2002 Nature Publishing Group Copyright Nature Publishing Group Jul 4, 2002 |
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| DOI | 10.1038/418038a |
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| SubjectTerms | Deoxyribonucleic acid DNA Gene expression Hepatitis Hepatitis C Medical research Vertebrates |
| Title | Gene expression RNA interference in adult mice |
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