Selective Photoinactivation of Methicillin‐Resistant Staphylococcus aureus by Highly Positively Charged RuII Complexes

Ruthenium(II) polypyridyl complexes featuring peripheral quaternary ammonium structures were found to be able to selectively inactivate Gram‐positive Staphylococcus aureus (S. aureus), including methicillin‐resistant S. aureus (MRSA) upon visible light irradiation, but have low phototoxicity toward...

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Published inChemistry : a European journal Vol. 25; no. 61; pp. 13879 - 13884
Main Authors Feng, Yang, Sun, Wei‐Ze, Wang, Xue‐Song, Zhou, Qian‐Xiong
Format Journal Article
LanguageEnglish
Published Weinheim Wiley Subscription Services, Inc 04.11.2019
Subjects
Ammonium
Antimicrobial agents
antimicrobial photodynamic therapy
Chemistry
Drug resistance
Erythrocytes
Irradiation
Light irradiation
Methicillin
methicillin-resistant Staphylococcus aureus
Pathogens
Photodynamic therapy
Photoinactivation
Phototoxicity
Radiation
reactive oxygen species
Ruthenium
Ruthenium compounds
ruthenium(II) polypyridyl complexes
selectivity
Staphylococcus aureus
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Abstract Ruthenium(II) polypyridyl complexes featuring peripheral quaternary ammonium structures were found to be able to selectively inactivate Gram‐positive Staphylococcus aureus (S. aureus), including methicillin‐resistant S. aureus (MRSA) upon visible light irradiation, but have low phototoxicity toward 293T cells, L02 cells and lack hemolysis toward rabbit red blood cells (RBC), exhibiting promising potential as a novel type of antimicrobial photodynamic therapy (aPDT) agents. Ruthenium(II) polypyridyl complexes featuring peripheral quaternary ammonium structures were found to be able to selectively inactivate MRSA but have extremely low cytotoxicity toward mammalian cells upon visible light irradiation.
AbstractList Ruthenium(II) polypyridyl complexes featuring peripheral quaternary ammonium structures were found to be able to selectively inactivate Gram-positive Staphylococcus aureus (S. aureus), including methicillin-resistant S. aureus (MRSA) upon visible light irradiation, but have low phototoxicity toward 293T cells, L02 cells and lack hemolysis toward rabbit red blood cells (RBC), exhibiting promising potential as a novel type of antimicrobial photodynamic therapy (aPDT) agents.Ruthenium(II) polypyridyl complexes featuring peripheral quaternary ammonium structures were found to be able to selectively inactivate Gram-positive Staphylococcus aureus (S. aureus), including methicillin-resistant S. aureus (MRSA) upon visible light irradiation, but have low phototoxicity toward 293T cells, L02 cells and lack hemolysis toward rabbit red blood cells (RBC), exhibiting promising potential as a novel type of antimicrobial photodynamic therapy (aPDT) agents.
Ruthenium(II) polypyridyl complexes featuring peripheral quaternary ammonium structures were found to be able to selectively inactivate Gram‐positive Staphylococcus aureus (S. aureus), including methicillin‐resistant S. aureus (MRSA) upon visible light irradiation, but have low phototoxicity toward 293T cells, L02 cells and lack hemolysis toward rabbit red blood cells (RBC), exhibiting promising potential as a novel type of antimicrobial photodynamic therapy (aPDT) agents.
Ruthenium(II) polypyridyl complexes featuring peripheral quaternary ammonium structures were found to be able to selectively inactivate Gram‐positive Staphylococcus aureus (S. aureus), including methicillin‐resistant S. aureus (MRSA) upon visible light irradiation, but have low phototoxicity toward 293T cells, L02 cells and lack hemolysis toward rabbit red blood cells (RBC), exhibiting promising potential as a novel type of antimicrobial photodynamic therapy (aPDT) agents. Ruthenium(II) polypyridyl complexes featuring peripheral quaternary ammonium structures were found to be able to selectively inactivate MRSA but have extremely low cytotoxicity toward mammalian cells upon visible light irradiation.
Author Wang, Xue‐Song
Zhou, Qian‐Xiong
Feng, Yang
Sun, Wei‐Ze
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Snippet Ruthenium(II) polypyridyl complexes featuring peripheral quaternary ammonium structures were found to be able to selectively inactivate Gram‐positive...
Ruthenium(II) polypyridyl complexes featuring peripheral quaternary ammonium structures were found to be able to selectively inactivate Gram-positive...
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SubjectTerms Ammonium
Antimicrobial agents
antimicrobial photodynamic therapy
Chemistry
Drug resistance
Erythrocytes
Irradiation
Light irradiation
Methicillin
methicillin-resistant Staphylococcus aureus
Pathogens
Photodynamic therapy
Photoinactivation
Phototoxicity
Radiation
reactive oxygen species
Ruthenium
Ruthenium compounds
ruthenium(II) polypyridyl complexes
selectivity
Staphylococcus aureus
Title Selective Photoinactivation of Methicillin‐Resistant Staphylococcus aureus by Highly Positively Charged RuII Complexes
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fchem.201903923
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