Selective Photoinactivation of Methicillin‐Resistant Staphylococcus aureus by Highly Positively Charged RuII Complexes

• Published in: Chemistry : a European journal Vol. 25; no. 61; pp. 13879 - 13884
• Main Authors: Feng, Yang, Sun, Wei‐Ze, Wang, Xue‐Song, Zhou, Qian‐Xiong
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 04.11.2019
• Subjects: Ammonium; Antimicrobial agents; antimicrobial photodynamic therapy; Chemistry; Drug resistance; Erythrocytes; Irradiation; Light irradiation; Methicillin; methicillin-resistant Staphylococcus aureus; Pathogens; Photodynamic therapy; Photoinactivation; Phototoxicity; Radiation; reactive oxygen species; Ruthenium; Ruthenium compounds; ruthenium(II) polypyridyl complexes; selectivity; Staphylococcus aureus
• ISSN: 0947-6539; 1521-3765; 1521-3765
• DOI: 10.1002/chem.201903923

Ruthenium(II) polypyridyl complexes featuring peripheral quaternary ammonium structures were found to be able to selectively inactivate Gram‐positive Staphylococcus aureus (S. aureus), including methicillin‐resistant S. aureus (MRSA) upon visible light irradiation, but have low phototoxicity toward 293T cells, L02 cells and lack hemolysis toward rabbit red blood cells (RBC), exhibiting promising potential as a novel type of antimicrobial photodynamic therapy (aPDT) agents. Ruthenium(II) polypyridyl complexes featuring peripheral quaternary ammonium structures were found to be able to selectively inactivate MRSA but have extremely low cytotoxicity toward mammalian cells upon visible light irradiation.