Continuous production mode as a viable process-engineering tool for efficient poly bio-production

Poly(hydroxyalkanoates) (PHAs) constitute promising biomaterials for substituting plastics of fossil origin. Until now, all commercial processes for PHA production were based on discontinuous fed-batch cultivation of prokaryotes. Such processes embody several shortcomings: unpredictable product qual...

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Bibliographic Details
Published inChemical and biochemical engineering quarterly Vol. 28; no. 1; p. 65
Main Authors Koller, M, Muhr, A
Format Journal Article
LanguageEnglish
Published Croatian Association of Chemical Engineers 2014
Subjects
Biomedical materials
Chemical engineering
Chemical engineering research
Chemical processes
Chemical properties
Production processes
Austria
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ISSN0352-9568

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Summary:Poly(hydroxyalkanoates) (PHAs) constitute promising biomaterials for substituting plastics of fossil origin. Until now, all commercial processes for PHA production were based on discontinuous fed-batch cultivation of prokaryotes. Such processes embody several shortcomings: unpredictable product quality, restricted possibility for supply of toxic carbon substrates, and, most of all, low volumetric productivity. Continuous PHA biosynthesis as a remedy was already investigated on laboratory scale for production of highly crystalline PHA homopolyesters as well as for elastomeric and even functional PHA copolyesters. Apart from enhanced productivity, chemostat processes are a feasible method to elucidate kinetics of cell growth and PHA formation under constant environmental conditions. In order to adapt the process engineering to the microbial kinetic characteristics for growth and PHA accumulation, continuous single- and multistage approaches are reported. Key words: Azohydromonas lata, bioreactor cascade, chemostat, continuous process, copolyester, Cupriavidus necator, (Poly)hydroxyalkanoates (PHA), Pseudomonas
ISSN:0352-9568