Comparison of morphine with fentanyl added to intrathecal 0.5% hyperbaric bupivacaine for analgesia after caesarean section

This was a prospective randomised, controlled, single-blind study done to determine the effect of intrathecal morphine 0.1 mg as compared with intrathecal fentanyl 25 microg in terms of analgesia and duration for postoperative pain relief after Caesarean section. Sixty ASA I or II parturients were r...

Full description

Saved in:
Bibliographic Details
Published inMedical journal of Malaysia Vol. 64; no. 1; p. 71
Main Authors Siti Salmah, G, Choy, Y C
Format Journal Article
LanguageEnglish
Published Malaysia 01.03.2009
Subjects
Adult
Analgesia, Obstetrical
Bupivacaine - administration & dosage
Bupivacaine - adverse effects
Cesarean Section
Female
Fentanyl - administration & dosage
Fentanyl - adverse effects
Humans
Injections, Spinal
Morphine - administration & dosage
Morphine - adverse effects
Pain, Postoperative - drug therapy
Pregnancy
Prospective Studies
Single-Blind Method
Online AccessGet full text

Cover

More Information
Summary:This was a prospective randomised, controlled, single-blind study done to determine the effect of intrathecal morphine 0.1 mg as compared with intrathecal fentanyl 25 microg in terms of analgesia and duration for postoperative pain relief after Caesarean section. Sixty ASA I or II parturients were randomised into two groups. Group 1 (n=33) received 1.8 ml of 0.5% hyperbaric bupivacaine combined with 0.1 mg morphine while Group 2 (n=27) received 1.8 ml of 0.5% hyperbaric bupivacaine combined with 25 microg fentanyl for spinal anaesthesia. Postoperatively, all patients were provided with patient controlled analgesia (PCA) morphine. Pain was assessed using visual analogue score (VAS) at 6, 12, 18 and 24 hours. Time to first demand of PCA morphine, cumulative PCA morphine requirement and opioid side effects were documented. The VAS for pain and the cumulative PCA morphine requirement were both significantly lower in Group 1 (p < 0.05) during the 24 hours study period. The time to first demand was also significantly longer in Group 1 (p < 0.05). Overall, there were no significant difference between the two groups in side effects, except for a high incidence of nausea and vomiting requiring treatment in Group B in the first six hours. In conclusion the addition of 0.1 mg morphine for spinal anaesthesia provided superior and longer postoperative analgesia after Caesarean section.
ISSN:0300-5283