MnOx Nanospikes as Nanoadjuvants and Immunogenic Cell Death Drugs with Enhanced Antitumor Immunity and Antimetastatic Effect

Despite the widespread applications of manganese oxide nanomaterials (MONs) in biomedicine, the intrinsic immunogenicity of MONs is still unclear. MnOx nanospikes (NSs) as tumor microenvironment (TME)‐responsive nanoadjuvants and immunogenic cell death (ICD) drugs are proposed for cancer nanovaccine...

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Published inAngewandte Chemie International Edition Vol. 59; no. 38; pp. 16381 - 16384
Main Authors Ding, Binbin, Zheng, Pan, Jiang, Fan, Zhao, Yajie, Wang, Meifang, Chang, Mengyu, Ma, Ping'an, Lin, Jun
Format Journal Article
LanguageEnglish
Published Weinheim Wiley Subscription Services, Inc 14.09.2020
EditionInternational ed. in English
Subjects
Anticancer properties
Antigens
Antitumor activity
Apoptosis
Cell death
Drugs
Ferroptosis
Immunity
immunogenic cell death
Immunogenicity
Immunotherapy
Magnetic resonance
Magnetic resonance imaging
Manganese
manganese oxide
Manganese oxides
Metastases
Nanomaterials
Nanotechnology
nanovaccines
Ovalbumin
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Summary:Despite the widespread applications of manganese oxide nanomaterials (MONs) in biomedicine, the intrinsic immunogenicity of MONs is still unclear. MnOx nanospikes (NSs) as tumor microenvironment (TME)‐responsive nanoadjuvants and immunogenic cell death (ICD) drugs are proposed for cancer nanovaccine‐based immunotherapy. MnOx NSs with large mesoporous structures show ultrahigh loading efficiencies for ovalbumin and tumor cell fragment. The combination of ICD via chemodynamic therapy and ferroptosis inductions, as well as antigen stimulations, presents a better synergistic immunopotentiation action. Furthermore, the obtained nanovaccines achieve TME‐responsive magnetic resonance/photoacoustic dual‐mode imaging contrasts, while effectively inhibiting primary/distal tumor growth and tumor metastasis. MnOx nanospikes serve as tumor microenvironment‐responsive nanoadjuvants and immunogenic cell death drugs for cancer nanovaccine‐based immunotherapy. They induce immunogenic cell death via chemodynamic therapy and ferroptosis, thereby enhancing antitumor immunity and antimetastatic effect. Key: glutathione (GSH), glutathione peroxidase 4 (GPX4), magnetic resonance imaging (MRI), near infrared (NIR), photoacoustic imaging (PAI).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.202005111