The effect of red grape juice on Alzheimer's disease in rats

• Published in: Advanced biomedical research Vol. 1; no. 1; p. 63
• Main Authors: Siahmard, Zahra, Alaei, Hojjatollah, Reisi, Parham, Pilehvarian, Ali Asghar
• Format: Journal Article
• Language: English
• Published: India Medknow Publications and Media Pvt. Ltd 2012; Medknow Publications & Media Pvt Ltd
• Subjects: Alzheimer's disease; Care and treatment; Grape juice; Health aspects; Original; Iran; streptozotocin; red grape juice; avoidance learning test; Alzheimer's disease
• ISSN: 2277-9175; 2277-9175
• DOI: 10.4103/2277-9175.100188

Alzheimer's disease is a neurodegenerative disease appearing as a result of free radicals and oxidative stress. Antioxidants agents boost memory and control Alzheimer's disease. Since red grape juice contains antioxidant agents, its effects on speed of learning and improvement of memory was studied in Alzheimer's rats. Alzheimer's model was induced by bilateral infusion of streptozocine into lateral ventricles of brain of male rats. Rats drank 10% red grape juice for 21 days. Passive avoidance learning test was used for measuring memory and learning in rats. Our results showed that learning and memory in STZ-group decreased significantly compared to Sham group. However, intake of red grape juice increased speed of learning and improvement of memory in Alzheimer's rats. Our results suggest that there are active ingredients in red grape juice, which probably have therapeutic and preventive effects on cognitive impairments in Alzheimer's disease.