Effect of Royal Jelly on spatial learning and memory in rat model of streptozotocin-induced sporadic Alzheimer's disease

• Published in: Advanced biomedical research Vol. 1; no. 1; p. 26
• Main Authors: Zamani, Zohre, Reisi, Parham, Alaei, Hojjatallah, Pilehvarian, Ali Asghar
• Format: Journal Article
• Language: English
• Published: India Medknow Publications and Media Pvt. Ltd 2012; Medknow Publications & Media Pvt Ltd
• Subjects: Alzheimer's disease; Care and treatment; Health aspects; Memory; Original; Risk factors; Royal jelly; Iran; Royal jelly; rat; streptozotocin; Alzheimer's disease; spatial learning and memory
• ISSN: 2277-9175; 2277-9175
• DOI: 10.4103/2277-9175.98150

It has been recently demonstrated that Royal jelly (RJ) has a beneficial role on neural functions. Alzheimer's disease (AD) is associated with impairments of learning and memory. Therefore, the present study was designed to examine the effect of RJ on spatial learning and memory in rats after intracerebroventricular injection of streptozotocin (icv-STZ). Rats were infused bilaterally with an icv injection of STZ, while sham rats received vehicle only. The rats were feed with RJ-contained food (3% w/w) (lyophilized RJ mixed with powdered regular food) or regular food for 10 days. Then spatial learning and memory was tested in the rats by Morris water maze test. Results showed that in icv-STZ group latency and path length were increased as compared to sham group, also icv-STZ rats less remembered the target quadrant that previously the platform was located; however, these were protected significantly in STZ group that received RJ-containing food. Our findings support the potential neuroprotective role of RJ and its helpful effects in AD.