Black grapes can change the physiology of adipose tissue in high-fat diets containing flaxseed oil or corn oil in C57BL/6J Mice

This study was conducted to clarify the efficacy of grapes against adipose tissue weight gain and hypertrophy of adipocytes. Additionally, we investigated the expression of PPARγ and glucose homeostasis of mice. 75 C57BL/6J male mice were randomly divided into control group and four high-fat diet (H...

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Bibliographic Details
Published inCurrent topics in nutraceuticals research Vol. 14; no. 4; p. 265
Main Authors Zamaninour, N, Ansar, H, Djazayery, A, Pishva, H, Shidfar, F, Fard, R. Mazaheri Nezhad, Dilmaghanian, A, Janani, L, Mirzaei, K, Bashiri, S, Vafa, M
Format Journal Article
LanguageEnglish
Published Coppell New Century Health Publishers, LLC 01.11.2016
Subjects
Adipocytes
Biosynthesis
Body fat
Diabetes
Diet
Fatty acids
Gene expression
Genetic aspects
Grapes
Health aspects
Homeostasis
Insulin resistance
Laboratory animals
Obesity
Polyphenols
Prevention
Studies
Transcription factors
Veterinary medicine
Weight gain
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Summary:This study was conducted to clarify the efficacy of grapes against adipose tissue weight gain and hypertrophy of adipocytes. Additionally, we investigated the expression of PPARγ and glucose homeostasis of mice. 75 C57BL/6J male mice were randomly divided into control group and four high-fat diet (HFD) groups containing corn oil + sugar (CO+S), corn oil + grape (CO +G), flaxseed oil + sugar (FO+S) and flaxseed oil + grape (FO + G). Diets were provided for 12 weeks. Adipose tissue weight, serum biochemical parameters, adipocyte size and PPARγ gene expression were measured. Adipose tissue weights in HFD groups increased compared to the control group; however, no significant difference was observed between FO+G and the control groups in four parts and between CO+G and the control groups in two parts (p>0.05). The size of adipocyte was less in mice fed diets containing grapes compared to other HFD groups (FO+G: 3699.88; FO+S: 4823.25; CO+G: 4153.25; CO+S: 5779.75 µm^sup 2^). Blood glucose in the CO+G was higher than the control group (p=0.022). No significant difference in PPARγ gene expression was observed (p>0.05). The results suggested that use of grapes might be a way to reduce the excessive accumulation of adipose tissue induced by HFD
ISSN:1540-7535
2641-452X