"Clickable" Hydrosoluble PEGylated Cryptophane as a Universal Platform for 129Xe Magnetic Resonance Imaging Biosensors
We describe the synthesis of a highly water‐soluble cryptophane 1 that can be seen as a universal platform for the construction of 129Xe magnetic resonance imaging (MRI)‐based biosensors. Compound 1 is easily functionalized by Huisgen cycloaddition and exhibits excellent xenon‐encapsulation properti...
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Published in | Chemistry : a European journal Vol. 19; no. 19; pp. 6089 - 6093 |
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Main Authors | , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Weinheim
WILEY-VCH Verlag
03.05.2013
WILEY‐VCH Verlag Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
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Summary: | We describe the synthesis of a highly water‐soluble cryptophane 1 that can be seen as a universal platform for the construction of 129Xe magnetic resonance imaging (MRI)‐based biosensors. Compound 1 is easily functionalized by Huisgen cycloaddition and exhibits excellent xenon‐encapsulation properties. In addition, 1 is nontoxic at the concentrations typically used for hyperpolarized 129Xe MRI.
Tales from the cryptophane: The synthesis is described of a cryptophane (1), highly soluble in water, that can be seen as a universal platform for the construction of 129Xe magnetic resonance imaging based biosensors. Compound 1 is easily functionalized by Huisgen cycloaddition and presents excellent xenon‐encapsulation properties (see figure). |
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Bibliography: | istex:1E8418D2CD9C0B525CC5FFDB5B12714058E23729 ArticleID:CHEM201204218 ark:/67375/WNG-NJJH2JKW-Z Fondation pour la Recherche Médicale - No. DCM20111223065 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0947-6539 1521-3765 |
DOI: | 10.1002/chem.201204218 |