"Clickable" Hydrosoluble PEGylated Cryptophane as a Universal Platform for 129Xe Magnetic Resonance Imaging Biosensors

• Published in: Chemistry : a European journal Vol. 19; no. 19; pp. 6089 - 6093
• Main Authors: Delacour, Léa, Kotera, Naoko, Traoré, Ténin, Garcia-Argote, Sébastien, Puente, Céline, Leteurtre, François, Gravel, Edmond, Tassali, Nawal, Boutin, Céline, Léonce, Estelle, Boulard, Yves, Berthault, Patrick, Rousseau, Bernard
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 03.05.2013; WILEY‐VCH Verlag; Wiley Subscription Services, Inc
• Subjects: Biosensing Techniques - methods; biosensors; cage compounds; Chemistry; Click Chemistry; cryptophane; Magnetic Resonance Spectroscopy - methods; NMR; NMR spectroscopy; Nuclear magnetic resonance; Polycyclic Compounds - chemistry; Software; Water; xenon; Xenon - chemistry
• ISSN: 0947-6539; 1521-3765
• DOI: 10.1002/chem.201204218

We describe the synthesis of a highly water‐soluble cryptophane 1 that can be seen as a universal platform for the construction of 129Xe magnetic resonance imaging (MRI)‐based biosensors. Compound 1 is easily functionalized by Huisgen cycloaddition and exhibits excellent xenon‐encapsulation properties. In addition, 1 is nontoxic at the concentrations typically used for hyperpolarized 129Xe MRI. Tales from the cryptophane: The synthesis is described of a cryptophane (1), highly soluble in water, that can be seen as a universal platform for the construction of 129Xe magnetic resonance imaging based biosensors. Compound 1 is easily functionalized by Huisgen cycloaddition and presents excellent xenon‐encapsulation properties (see figure).