A General Method to Establish the Relative Efficiency of Different Sonosensitizers to Generate ROS for SDT

The most common way to demonstrate the reactive oxygen species (ROS)-mediated pathways in photodynamic therapy (PDT) and in sonodynamic therapy (SDT) is the use of specific ROS inhibitors. We present a general method to establish the relative efficiency of different sonosensitizers which produce the...

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Bibliographic Details
Published inMethods in molecular biology (Clifton, N.J.) Vol. 2202; p. 189
Main Authors Grosso, Viviana, Senz, Alejandro, Soltermann, Arnaldo T
Format Journal Article
LanguageEnglish
Published United States 2021
Subjects
Acoustic Stimulation - methods
Apoptosis
Humans
Photochemotherapy - methods
Reactive Oxygen Species - analysis
Singlet Oxygen - analysis
Singlet Oxygen - metabolism
Sound
Cavitation phenomena
SDT
Cancer treatment
Sonodynamic effect
ROS
Singlet molecular oxygen
Sonoirradiator
Sonosensitizer
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Summary:The most common way to demonstrate the reactive oxygen species (ROS)-mediated pathways in photodynamic therapy (PDT) and in sonodynamic therapy (SDT) is the use of specific ROS inhibitors. We present a general method to establish the relative efficiency of different sonosensitizers which produce the same ROS. To demonstrate it, we use peroxides as sonosensitizers which produce singlet molecular oxygen. The method is easily generalized by all types of ROS.
ISSN:1940-6029
DOI:10.1007/978-1-0716-0896-8_15