Randomized Controlled Trials 2: Analysis

When analyzing the results of a trial, the primary outcome variable must be kept in clear focus. In the analysis plan, consideration must be given to comparing the characteristics of the subjects, taking account of differences in these characteristics, intention-to-treat analysis, interim analyses a...

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Bibliographic Details
Published inMethods in molecular biology (Clifton, N.J.) Vol. 2249; p. 213
Main Authors Foley, Robert N, Parfrey, Patrick S
Format Journal Article
LanguageEnglish
Published United States 2021
Subjects
Stopping rules
Intention to treat
Composite outcomes
Analysis
Multivariate modeling
Competing risks
Research design
Statistical power
Subgroups
Randomized controlled trials
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Summary:When analyzing the results of a trial, the primary outcome variable must be kept in clear focus. In the analysis plan, consideration must be given to comparing the characteristics of the subjects, taking account of differences in these characteristics, intention-to-treat analysis, interim analyses and stopping rules, mortality comparisons, composite outcomes, research design including run-in periods, factorial, stratified and crossover designs, number needed to treat, power issues, multivariate modeling, subgroup analysis, competing risks, and hypothesis-generating analyses.
ISSN:1940-6029
DOI:10.1007/978-1-0716-1138-8_12