The Interface between Immunotransfusion and Hemostasis and Thrombosis Testing

• Published in: Methods in molecular biology (Clifton, N.J.) Vol. 1646; p. 43
• Main Author: Franchini, Massimo
• Format: Journal Article
• Language: English
• Published: United States 2017
• Subjects: ABO Blood-Group System - analysis; ABO Blood-Group System - blood; Animals; Blood Coagulation Tests - methods; Blood Platelets - pathology; Blood Transfusion - methods; Erythrocytes - pathology; Hemostasis; Humans; Risk Factors; Thrombosis - blood; Thrombosis - diagnosis; Thrombosis - etiology; Thrombosis - pathology; Transfusion Reaction - blood; Transfusion Reaction - complications; Transfusion Reaction - diagnosis; Transfusion Reaction - pathology; ABO blood group system; Red blood cells; Platelets; Fresh frozen plasma; Thrombosis
• ISSN: 1940-6029
• DOI: 10.1007/978-1-4939-7196-1_3

Increasing evidence supports the existence of a close relationship between immunotransfusion, hemostasis, and thrombosis. The best example of such linkage is given by the influence of the ABO blood group antigens on von Willebrand factor (VWF) plasma levels and activity. It is well known, for instance, that individuals with non-O blood type (i.e., A, B, and AB) have higher VWF and factor VIII plasma levels than O blood type subjects and are consequently exposed to an increased thrombotic risk. There is also a close relationship between immunotransfusion, hemostasis, and thrombosis testing. The first part of this narrative review is dedicated to the issue of the relationship between immunotransfusion, hemostasis, and thrombosis, while the second part is focused on the relationship between immunotransfusion and hemostasis and thrombosis testing, as well as the effects on hemostasis of the transfusion of blood components (i.e., red blood cells, platelet concentrates, and fresh frozen plasma) and plasma-derived products.