Complexes of selected late period lanthanide contrast agents

A series of 18 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid amide (DOTAM)-alkyl derived complexes with selected late lanthanide (III) cations ([Dy.sup.3+], [Tb.sup.3+], and [Tm.sup.3+]) has been synthesized; their magnetic properties have been evaluated and compared to those derived from...

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Bibliographic Details
Published inCanadian journal of chemistry Vol. 91; no. 3; pp. 211 - 219
Main Authors Elmehriki, Adam A.H, Milne, Mark, Suchy, Mojmir, Bartha, Robert, Hudson, Robert H.E
Format Journal Article
LanguageEnglish
Published NRC Research Press 01.03.2013
Subjects
Acetic acid
Amides
Cations
Chemical properties
Chemical synthesis
Composition
Ligands
Magnetic properties
Methods
Paramagnetism
Production processes
Rare earth metals
Canada
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Summary:A series of 18 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid amide (DOTAM)-alkyl derived complexes with selected late lanthanide (III) cations ([Dy.sup.3+], [Tb.sup.3+], and [Tm.sup.3+]) has been synthesized; their magnetic properties have been evaluated and compared to those derived from DOTAM. Peralkylation of cyclen with correspondingN-iodoacetyl amines was utilized as the key step in the synthesis. Chemical exchange saturation transfer (CEST) spectra of the complexes have been acquired at 37°C, revealing that [Tm.sup.3+]-derived DOTAM-alkyl complexes possess the most favorable properties as potential paramagnetic chemical exchange saturation transfer (PARACEST) magnetic resonance imaging (MRI) contrast agents.
ISSN:0008-4042
1480-3291
DOI:10.1139/cjc-2012-0358