CYTOTOXIC PROPERTIES OF CLINOPODIUM VULGARE L. EXTRACTS ON SELECTED HUMAN CELL LINES

Plants of Lamiaceae family are highly recommended as a source for new pharmaceuticals due to their wide range of biological activities. We have further investigated the in vitro effects of acidified, alkalized and lipophilic extracts of the medicinal plant Clinopodium vulgare L. on the cell viabilit...

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Published inComptes rendus de l'Academie bulgare des Sciences Vol. 70; no. 5; p. 645
Main Authors Batsalova, Tsvetelina, Bardarov, Krum, Bardarov, Ventzislav, Moten, Dzhemal, Dzhambazov, Balik
Format Journal Article
LanguageEnglish
Published Bulgarian Academy of Sciences 01.01.2017
Subjects
Antineoplastic agents
Evaluation
Health aspects
Lamiaceae
Medicinal plants
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Summary:Plants of Lamiaceae family are highly recommended as a source for new pharmaceuticals due to their wide range of biological activities. We have further investigated the in vitro effects of acidified, alkalized and lipophilic extracts of the medicinal plant Clinopodium vulgare L. on the cell viability of selected cell lines. In vitro cytotoxicity was evaluated against CaOV (human testis cystadenocarcinoma), HeLa (human cervical adenocarcinoma), HT-29 (human colorectal adenocarcinoma) and FL (human amnion normal) cell lines using MTT assay. We found that two of the extracts (acidified and lipophilic) exerted selective dose-dependent cytotoxic activity against CaOV (I[C.sub.50]: 225-260.86 [micro]g/mL) and HeLa cells (I[C.sub.50]: 360.27-388.5 [micro]g/mL), while the cytotoxicity of the alkalized extract against these cell lines was less pronounced. All tested extracts showed very weak or lack of cytotoxic actions towards HT-29 and the normal FL cells. Moreover, these results indicate that Clinopodium vulgare extracts possess selective anticancer activity and could serve as a source for isolation and development of new therapeutic anticancer agents.Key words: Clinopodium vulgare, cytotoxicity, anticancer activity, in vitro
ISSN:1310-1331