HBA1C as a Dual Marker for the Detection of Lipid Profile and Cardiovascular Disease in Type-I Diabetic Subjects

• Published in: Pakistan journal of zoology Vol. 53; no. 2; p. 699
• Main Authors: Sadiq, Ahmad, Shah, Muzafar, Ullah, Habib, Ali, Irfan, Alam, Amir, Jalil, Navid, Khan, Muhammad
• Format: Journal Article
• Language: English
• Published: Lahore Knowledge Bylanes 30.04.2021; AsiaNet Pakistan (Pvt) Ltd
• Subjects: Abnormalities; Angina; Angina pectoris; Automation; Blood pressure; Body mass; Body mass index; Body size; Cardiovascular disease; Cardiovascular diseases; Cholesterol; Comparative analysis; Complications; Coronary artery disease; Density; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Experiments; Females; Glucose; Health aspects; Health care facilities; Heart diseases; Hematology; Hemoglobin; High density lipoprotein; Hyperglycemia; Hypertension; Insulin resistance; Ischemia; Laboratories; Lipids; Low density lipoprotein; Males; Metabolism; Obesity; Physiological aspects; Statistical analysis; Stroke; Triglycerides; Type 1 diabetes; Pakistan; Peshawar Pakistan; Germany
• ISSN: 0030-9923
• DOI: 10.17582/journal.pjz/20190911090946

Diabetic patients are deliberated to be at greater risk of hypertension and lipid abnormalities, which are the main cause of cardiovascular diseases (CVD). The present work revealed the role of glycated hemoglobin (HbA1c) for the detection of lipid profile and CVD. In recent study 108 (56 males and 52 female) type 2 diabetes (T2DM) subjects were diagnosed at Hayatabad Medical Complex (HMC) Peshawar and private diabetic clinic “Khattak Medical Centre” (KMC), Dabgari Garden Peshawar, Khyber Pakhtunkhwa, Pakistan. The normal or control group consists of twenty (9 females and 11 males) people having no history of diabetes mellitus, hypertension and cardiovascular disease. Glycated hemoglobin HbA1c, random blood sugar (RBS) triglycerides (TG) total cholesterol (TC) systolic blood pressure (SBP) and diastolic blood pressure (DBP) were significantly higher in patients (p<0.05) than normal or controlled. In patients with low density lipoprotein (LDL), high density lipoprotein (HDL) and body mass index (BMI) were found to be significantly lower (p > 0.05) than normal or control. Gender-based analysis has shown that HbA1c, RBS, DBP and SBP in male patients have significantly higher (p<0.05) than female. But in female patients the TC, TG and BMI are insignificantly higher (p<0.05) compared to male. High density lipoprotein (HDL) was found same in both male and female. Moreover, patients with HbA1c > 7 have 26.66% stroke, 4.44% angina, 2.22% ischemic heart disease and 27.77% micro vascular complications.