Pathologic Lymph Node Staging of Gastric Cancer: Current Challenges and Controversies

• Published in: American journal of clinical pathology Vol. 156; no. 5; pp. 749 - 765
• Main Authors: del Arco, Cristina Diaz, Medina, Luis Ortega, Munoz, Lourdes Estrada, de las Heras, Soledad Garcia Gomez, Acenero, M. Jesus Fernandez
• Format: Journal Article
• Language: English
• Published: Chicago Oxford University Press 01.11.2021
• Subjects: Analysis; Biopsy; Cancer; Classification; Gastric cancer; Literature reviews; Lymph nodes; Lymphatic system; Medical prognosis; Metastases; Metastasis; Stomach cancer; Tumor staging
• ISSN: 0002-9173; 1943-7722
• DOI: 10.1093/ajcp/aqab031

Objectives: The TNM classification is the main tool for lymph node (LN) staging in gastric cancer (GC). However, alternative LN staging systems have been proposed, and the role of features other than the number of metastatic LNs is being investigated. Our aim is to discuss the main challenges of LN assessment in GC. Methods: Comprehensive review of the literature on alternative LN staging systems, examined LNs, sentinel LN (SLN) biopsy, LN micrometastases (LNMIs), extracapsular extension (ECE), and tumor deposits (TDs) in GC. Results: Many controversies exist regarding LN assessment in GC. The TNM classification shows excellent prognostic performance, but alternative prognostic methods such as the LN ratio or log odds of positive LNs have demonstrated to be better than the TNM system in terms of prognostic accuracy. The value of SLN biopsy and LNMIs in GC is still unclear, and several challenges concerning their clinical impact and pathologic analysis must be overcome before their introduction in clinical practice. Most authors have identified ECE and TDs as independent prognostic factors for survival in GC. Conclusions: Further studies should be performed to evaluate the impact of these features on the TNM classification and patient outcomes, as well as to standardize alternative LN staging systems.