The expanding constellation of immune checkpoints: a DNAMic control by CD155

The clinical benefits that have been achieved for a group of cancer patients with metastatic disease on checkpoint inhibitor therapy have kindled intense interest in understanding tumor-induced escape from T lymphocyte control. Other lymphoid cells also participate in tumor control; in particular, N...

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Bibliographic Details
Published inThe Journal of clinical investigation Vol. 128; no. 6; pp. 2199 - 2201
Main Author Bronte, Vincenzo
Format Journal Article
LanguageEnglish
Published American Society for Clinical Investigation 01.06.2018
Subjects
Cancer metastasis
Care and treatment
Genetic aspects
Killer cells
T cells
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Summary:The clinical benefits that have been achieved for a group of cancer patients with metastatic disease on checkpoint inhibitor therapy have kindled intense interest in understanding tumor-induced escape from T lymphocyte control. Other lymphoid cells also participate in tumor control; in particular, NK cells can limit hematogenous cancer metastasis spread and are also subject to negative regulation by developing cancers. In this issue of the JCI, Li and colleagues define an unanticipated role for the stress-induced protein CD155 in cancer metastasis. The presence of CD155 on the surface of cancer cells was shown to promote tumor invasiveness, while its upregulation in tumor environment-infiltrating myeloid cells restrained antitumor immunity by impairing antitumor T lymphocytes and NK cell function. Together, these results support further exploration of strategies for targeting CD155.
ISSN:0021-9738
DOI:10.1172/JCH21229