Influence of 5-HTIA and 5-HTTLPR genetic variants on the schizophrenia symptoms and occurrence of treatment-resistant schizophrenia

This study aimed to explore the influence of two genetic polymorphisms of the 5-hydroxytryptamine 1A receptor (5-HT1A) and solute carrier family 6, member 4 (SLC6A4) genes on the clinical symptoms and treatment resistance in Slovenian patients with schizophrenia. A total of 138 patients with schizop...

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Published inNeuropsychiatric disease and treatment Vol. 11; p. 453
Main Authors Terzic, Tea, Kastelic, Matej, Dolzan, Vita, Plesnicar, Blanka Kores
Format Journal Article
LanguageEnglish
Published Dove Medical Press Limited 01.01.2015
Subjects
Analysis
Care and treatment
Drug therapy
Genetic polymorphisms
Hospital utilization
Length of stay
Neurophysiology
Risk factors
Schizophrenia
Slovenia
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Summary:This study aimed to explore the influence of two genetic polymorphisms of the 5-hydroxytryptamine 1A receptor (5-HT1A) and solute carrier family 6, member 4 (SLC6A4) genes on the clinical symptoms and treatment resistance in Slovenian patients with schizophrenia. A total of 138 patients with schizophrenia were evaluated using the Positive and Negative Syndrome Scale, Brief Psychiatric Rating Scale, Clinical Global Impression, and Global Assessment of Functioning. Based on the selected criteria, 94 patients were included in the treatment-responsive and 44 in the treatment-resistant group. All subjects and 94 controls were genotyped for the 5-HT1A rs6295 and 5-HTTLPR polymorphisms. There were no statistically significant differences in the frequencies of these polymorphisms between the patients with schizophrenia and the control group and between the treatment-resistant and treatment-responsive group of schizophrenia patients. Polymorphisms rs6295 and 5-HTTLPR had an influence on the Global Assessment of Functioning scale score, while 5-HTTLPR also had an influence on the total score of the negative subscale within the Positive and Negative Syndrome Scale. Although we found no effect on progression toward the treatment-resistant schizophrenia, our data suggest that the rs6295 and 5-HTTLPR polymorphisms can influence some clinical symptoms in schizophrenia. Keywords: genetic polymorphisms, serotonergic system, antipsychotics, SLC6A4, serotonergic receptor
ISSN:1176-6328
DOI:10.2147/NDT.S76494