Lowering [beta]-Amyloid Levels Rescues Learning and Memory in a Down Syndrome Mouse Model

[beta]-amyloid levels are elevated in Down syndrome (DS) patients throughout life and are believed to cause Alzheimer's disease (AD) in adult members of this population. However, it is not known if [beta]-amyloid contributes to intellectual disability in younger individuals. We used a [gamma]-s...

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Published inPloS one Vol. 5; no. 6; p. e10943
Main Authors Netzer, William J, Powell, Craig, Nong, Yi, Blundell, Jacqueline, Wong, Lili, Duff, Karen, Flajolet, Marc, Greengard, Paul
Format Journal Article
LanguageEnglish
Published Public Library of Science 03.06.2010
Subjects
Alzheimer's disease
Analysis
Down syndrome
Genetic aspects
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Summary:[beta]-amyloid levels are elevated in Down syndrome (DS) patients throughout life and are believed to cause Alzheimer's disease (AD) in adult members of this population. However, it is not known if [beta]-amyloid contributes to intellectual disability in younger individuals. We used a [gamma]-secretase inhibitor to lower [beta]-amyloid levels in young mice that model DS. This treatment corrected learning deficits characteristic of these mice, suggesting that [beta]-amyloid-lowering therapies might improve cognitive function in young DS patients.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0010943