Plasmodium vivax Pv12 B-cell epitopes and HLA-DR[beta]1-dependent T-cell epitopes in vitro antigenicity

Malaria is an infectious disease caused by parasites from the genus Plasmodium (P. falciparum and P. vivax are responsible for 90% of all clinical cases); it is widely distributed throughout the world's tropical and subtropical regions. The P. vivax Pv12 protein is involved in invasion, is expr...

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Published inPloS one Vol. 13; no. 9; p. e0203715
Main Authors Yepes-Pérez, Yoelis, López, Carolina, Suárez, Carlos Fernando, Patarroyo, Manuel Alfonso
Format Journal Article
LanguageEnglish
Published Public Library of Science 10.09.2018
Subjects
B cells
Causes of
Health aspects
Malaria
Malaria vaccines
Plasmodium falciparum
Risk factors
T cells
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Summary:Malaria is an infectious disease caused by parasites from the genus Plasmodium (P. falciparum and P. vivax are responsible for 90% of all clinical cases); it is widely distributed throughout the world's tropical and subtropical regions. The P. vivax Pv12 protein is involved in invasion, is expressed on merozoite surface and has been recognised by antibodies from individuals exposed to the disease. In this study, B- and T-cell epitopes from Pv12 were predicted and characterised to advance in the design of a peptide-based vaccine against malaria.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0203715