Risk factors and outcome due to extended-spectrum [beta]-lactamase-producing uropathogenic Escherichia coli in community-onset bloodstream infections: A ten-year cohort study in Sweden

• Published in: PloS one Vol. 17; no. 11; p. e0277054
• Main Authors: Holmbom, Martin, Möller, Vidar, Kristinsdottir, Loa, Nilsson, Maud, Rashid, Mamun-Ur, Fredrikson, Mats, Berglund, Björn, Östholm Balkhed, Åse
• Format: Journal Article
• Language: English
• Published: Public Library of Science 03.11.2022
• Subjects: Analysis; Antibiotics; Beta lactamases; Care and treatment; Diagnosis; Dosage and administration; Prevention; Risk factors; Sepsis; Urinary tract infections; Sweden
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0277054

To study clinical outcome and risk factors associated with extended-spectrum [beta]-lactamase (ESBL)-producing uropathogenic Escherichia coli (UPEC) in community-onset bloodstream infections (CO-BSI). This was a population-based cohort study including patients with pheno- and genotype-matched ESBL-producing E. coli and non-ESBL- E. coli in urine and blood samples collected in 2009-2018 in southeast Sweden. Seventy-seven episodes of ESBL-UPEC satisfying the inclusion criteria were matched 1:1 with 77 non-ESBL-UPEC for age, gender, and year of culture. The most common ST-type and ESBL gene was ST131 (55%), and bla.sub.CTX-M-15 (47%), respectively. Risk factors for ESBL-UPEC were: previous genitourinary invasive procedure (RR 4.66; p = 0.005) or history of ESBL-producing E. coli (RR 12.14; p = 0.024). There was significant difference between ESBL-UPEC and non-ESBL-UPEC regarding time to microbiologically appropriate antibiotic therapy (27:15 h vs. 02:14 h; p = <0.001) and hospital days (9 vs. 5; p = 0.999) or sepsis within 36 hours (51% vs. 62%; p = 0.623) was observed. The predominant risk factors for ESBL-UPEC were history of ESBL-Ec infection and history of genitourinary invasive procedure. The overall mortality was low and the delay in appropriate antibiotic therapy did not increase the risk for 30-day mortality or risk for sepsis within 36 hours among patients infected with ESBL UPEC. However, these results must be regarded with some degree of caution due to the small sample size.