Phosphorylation of Glycine Derivatives via Copper(I)-Catalyzed Csp3−H Bond Functionalization
A simple and efficient one‐pot approach has been developed for a copper‐catalyzed phosphorylation of glycine derivatives under air and at room temperature. The present cross‐dehydrogenative coupling allows various methoxyphenyl‐protected glycine derivatives to be phosphorylated using diverse alkyl a...
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Published in | Advanced synthesis & catalysis Vol. 358; no. 15; pp. 2553 - 2557 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Blackwell Publishing Ltd
28.07.2016
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Subjects | |
Online Access | Get full text |
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Summary: | A simple and efficient one‐pot approach has been developed for a copper‐catalyzed phosphorylation of glycine derivatives under air and at room temperature. The present cross‐dehydrogenative coupling allows various methoxyphenyl‐protected glycine derivatives to be phosphorylated using diverse alkyl and aryl phosphites through an oxidative coupling between Csp3−H and P−H bonds catalyzed by copper iodide. This method provides a new synthetic tool to obtain biologically active α‐aminophosphonates. |
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Bibliography: | NSERC Canada Research Chair Foundation istex:B9DB9D25A44CA2924759089AB1167AAD5345BA81 FQRNT Center for Green Chemistry and Catalysis CFI ArticleID:ADSC201600539 McGill University ark:/67375/WNG-V380M9TK-8 universities and principals overseas study plan in Jiangsu province for outstanding young and middle-aged teachers, China |
ISSN: | 1615-4150 1615-4169 |
DOI: | 10.1002/adsc.201600539 |