Phosphorylation of Glycine Derivatives via Copper(I)-Catalyzed Csp3−H Bond Functionalization

A simple and efficient one‐pot approach has been developed for a copper‐catalyzed phosphorylation of glycine derivatives under air and at room temperature. The present cross‐dehydrogenative coupling allows various methoxyphenyl‐protected glycine derivatives to be phosphorylated using diverse alkyl a...

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Bibliographic Details
Published inAdvanced synthesis & catalysis Vol. 358; no. 15; pp. 2553 - 2557
Main Authors Zhi, Huizhen, Ung, Sosthene Pierre-Marie, Liu, Yun, Zhao, Liang, Li, Chao-Jun
Format Journal Article
LanguageEnglish
Published Blackwell Publishing Ltd 28.07.2016
Subjects
aminophosphonates
copper
glycine derivatives
organophosphorus compounds
phosphorylation
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Summary:A simple and efficient one‐pot approach has been developed for a copper‐catalyzed phosphorylation of glycine derivatives under air and at room temperature. The present cross‐dehydrogenative coupling allows various methoxyphenyl‐protected glycine derivatives to be phosphorylated using diverse alkyl and aryl phosphites through an oxidative coupling between Csp3−H and P−H bonds catalyzed by copper iodide. This method provides a new synthetic tool to obtain biologically active α‐aminophosphonates.
Bibliography:NSERC
Canada Research Chair Foundation
istex:B9DB9D25A44CA2924759089AB1167AAD5345BA81
FQRNT Center for Green Chemistry and Catalysis
CFI
ArticleID:ADSC201600539
McGill University
ark:/67375/WNG-V380M9TK-8
universities and principals overseas study plan in Jiangsu province for outstanding young and middle-aged teachers, China
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201600539