Metal complexes of salicylhydroxamic acid and 1,10-phenanthroline; equilibrium and antimicrobial activity studies

Salicylhydroxamic acid and its binary and ternary copper(II), nickel(II), and iron(III) complexes involving 1,10-phenanthroline were studied pH-potentiometrically in 0.15 mol x [L.sup.-1] NaN[O.sub.3] aqueous solutions at 37°C. The protonation constants of salicylhydroxamic acid and 1,10-phenanthrol...

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Bibliographic Details
Published inBulletin of the Chemical Society of Ethiopia Vol. 28; no. 3; p. 393
Main Author Fazary, Ahmed E
Format Journal Article
LanguageEnglish
Published Chemical Society of Ethiopia 01.09.2014
Subjects
Analysis
Copper compounds
Drug discovery
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Summary:Salicylhydroxamic acid and its binary and ternary copper(II), nickel(II), and iron(III) complexes involving 1,10-phenanthroline were studied pH-potentiometrically in 0.15 mol x [L.sup.-1] NaN[O.sub.3] aqueous solutions at 37°C. The protonation constants of salicylhydroxamic acid and 1,10-phenanthroline as well their binary and mixed ligand complex species stability constants were determined based on 3 estimation models (Irving Rossetti, Bjerrum-Calvin and Hyperquad 2008). Also, six solid complexes were synthesized and their biological activities were evaluated against some pathogenic bacteria and fungi organisms. KEY WORDS: Salicylhydroxamic acid, 1,10-Phenanthroline, Potentiometry, Antifungal and antibacterial activities
ISSN:1011-3924
DOI:10.4314/bcse.v28i3.8