Synthesis of new derivatives of inositol-containing phospholipid dimer analogs as potential inhibitors of virus adsorption

The majority of known agents against human immunodeficiency virus (HIV) are targeted at the virus enzymes protease and integrase but do not prevent HIV entry into host cells. Therefore, it is critical to seek small polyanionic molecules as potential inhibitors of virus adsorption. Inositol-containin...

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Published inPharmaceutical chemistry journal Vol. 45; no. 6; p. 344
Main Authors Baranova, E.O, Dang, T. Ph. L, Eremin, S.V, Esipov, D.S, Shastina, N.S, Shvets, V.I
Format Journal Article
LanguageEnglish
Published Springer 01.09.2011
Subjects
Adsorption
Antiviral agents
Chemical properties
Inositol
Lead compounds
Lipids
Phosphonates
Proteases
Sulfates
Virus diseases
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Summary:The majority of known agents against human immunodeficiency virus (HIV) are targeted at the virus enzymes protease and integrase but do not prevent HIV entry into host cells. Therefore, it is critical to seek small polyanionic molecules as potential inhibitors of virus adsorption. Inositol-containing phospholipids, which are naturally occurring biologically active compounds that are involved in cell regulation, may be promising lead compounds for antiviral drug design. In the present study, dimer analogs of inositol-containing phospholipids were synthesized using the H-phosphonate method. Carboxymethyl and sulfate derivatives based on them were obtained and proposed as potential virus adsorption inhibitors. Key words: inositol-containing phospholipids, phosphorylation, polyanions, virus adsorption inhibitors.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-011-0630-y