Neil Bence: manipulating degradation.(research of protein degradation to study protein aggregation in neurodegenerative diseases)
[...]Kopito's lab was refocusing its efforts from endoplasmic reticulum-associated protein degradation in cystic fibrosis to the relevance of misfolded protein aggregations to neurodegenerative diseases. Bence and his collaborators found that protein aggregates were tied to impairment of the ub...
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Published in | The Scientist Vol. 26; no. 12; p. 57 |
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Main Author | |
Format | Journal Article Trade Publication Article |
Language | English |
Published |
Midland
Scientist Inc
01.12.2012
LabX Media Group |
Subjects | |
Online Access | Get full text |
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Summary: | [...]Kopito's lab was refocusing its efforts from endoplasmic reticulum-associated protein degradation in cystic fibrosis to the relevance of misfolded protein aggregations to neurodegenerative diseases. Bence and his collaborators found that protein aggregates were tied to impairment of the ubiquitin system.1 The finding could explain how tangles of proteins might become toxic to cells in patients with neurodegenerative or other diseases. |
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ISSN: | 0890-3670 1547-0806 |