Neil Bence: manipulating degradation.(research of protein degradation to study protein aggregation in neurodegenerative diseases)

[...]Kopito's lab was refocusing its efforts from endoplasmic reticulum-associated protein degradation in cystic fibrosis to the relevance of misfolded protein aggregations to neurodegenerative diseases. Bence and his collaborators found that protein aggregates were tied to impairment of the ub...

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Bibliographic Details
Published inThe Scientist Vol. 26; no. 12; p. 57
Main Author Grens, Kerry
Format Journal Article Trade Publication Article
LanguageEnglish
Published Midland Scientist Inc 01.12.2012
LabX Media Group
Subjects
Care and treatment
Degeneration
Graduate students
Health aspects
Nervous system
Neurodegeneration
Neurodegenerative diseases
Proteins
R&D
Research & development
Research scientists
Ubiquitin-proteasome system
United States
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Summary:[...]Kopito's lab was refocusing its efforts from endoplasmic reticulum-associated protein degradation in cystic fibrosis to the relevance of misfolded protein aggregations to neurodegenerative diseases. Bence and his collaborators found that protein aggregates were tied to impairment of the ubiquitin system.1 The finding could explain how tangles of proteins might become toxic to cells in patients with neurodegenerative or other diseases.
ISSN:0890-3670
1547-0806