A new porous Co(II)‐coordination polymer for the chemical fixation of CO2 and treatment effect against tuberculosis by reducing the pckA expression in Mycobacterium tuberculosis

• Published in: Applied organometallic chemistry Vol. 34; no. 11
• Main Authors: Yan, Li‐Ping, Sun, Qin, Liu, Zhi‐Bin, Wu, Min, Ge, Yan‐Ping, Zhang, Qing
• Format: Journal Article
• Language: English
• Published: 01.11.2020
• Subjects: CO2 fixation, coordination polymers, mixed ligand, molecular docking, Mycobacterium tuberculosis
• ISSN: 0268-2605; 1099-0739
• DOI: 10.1002/aoc.5908

Using the mixed‐ligand method, a novel coordination polymer containing Co(II) of [Co(ditb)(tdc)]n·5nH2O (1) was prepared by reacting rigid 2,5‐thiophenedicarboxylic acid with flexible 1,4‐di(1H‐1,2,4‐triazol‐1‐yl)butane using the slow evaporation method. Active samples of 1 (1a for short) showed good stability and the ability to capture CO2. It can be used as a potential heterogeneous catalyst for chemical immobilization of epoxide and CO2 to form cyclic carbonates. In addition, catalyst 1a retained its original structure after four times of reuse. Its biological properties were assessed against Mycobacterium tuberculosis (M.TB) both in vivo and in vitro. First, the bactericidal ability of the compound against M.TB was measured by a sterilization curve. Then, the expression of pckA gene related to M.TB survival was detected using reverse transcription‐polymerase chain reaction. For the in vivo study, the colony‐forming unit determination was performed for evaluating the anti‐bacterial effect of the compound, and the enzyme‐linked immunosorbent assay was used for the inflammatory cytokine measurement in vivo. Through molecular docking simulations, all three types of polar atoms on the complex were confirmed to have chances of interacting with the protein. A novel coordination polymer containing Co(II) was prepared using a mixed‐ligand approach. It can be used as a latent heterogeneous catalyst for chemical immobilization of epoxide and CO2 to form cyclic carbonates. In addition, the inhibition against Mycobacterium tuberculosis was assessed both in vivo and in vitro.