Attenuated Neuropathic Pain in Ca(V)3.1 Null Mice

• Published in: Molecules and cells pp. 242 - 246
• Main Authors: 나흥식, Soonwook Choi, 김준선, Joonoh Park, 신희섭
• Format: Journal Article
• Language: English
• Published: 한국분자세포생물학회 30.04.2008
• Subjects: 생물학
• ISSN: 1016-8478; 0219-1032

To assess the role of α1G T-type Ca2+ channels in neuropathic pain after L5 spinal nerve ligation, we examined behavioral pain susceptibility in mice lacking CaV3.1 (α1G −/−), the gene encoding the pore-forming units of these channels. Reduced spontaneous pain responses and an increased threshold for paw withdrawal in response to mechanical stimulation were observed in these mice. The α1G −/− mice also showed attenuated thermal hyperalgesia in response to both low-(IR30) and high-intensity (IR60) infrared stimulation. Our results reveal the importance of α1G T-type Ca2+ channels in the development of neuropathic pain, and suggest that selective modulation of α1G subtype channels may provide a novel approach to the treatment of allodynia and hyperalgesia. KCI Citation Count: 42