Recurrent Prostate Cancer Diagnostics with [sup.18]F-PSMA-1007 PET/CT: A Systematic Review of the Current State

Background: Early diagnosis of recurrent prostate cancer is a cornerstone for further adequate therapy planning. Therefore, clinical practice and research still focuses on diagnostic tools that can detect prostate cancer in early recurrence when it is undetectable in conventional diagnostic imaging....

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Published inDiagnostics (Basel) Vol. 12; no. 12
Main Authors Saule, Laura, Radzina, Maija, Liepa, Mara, Roznere, Lilita, Lioznovs, Andrejs, Ratniece, Madara, Mamis, Edgars, Vjaters, Egils
Format Journal Article
LanguageEnglish
Published MDPI AG 01.12.2022
Subjects
Cancer
CT imaging
Diagnosis
Diseases
Metastasis
Methods
PET imaging
Prostate cancer
Relapse
Tracers (Biology)
Latvia
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Summary:Background: Early diagnosis of recurrent prostate cancer is a cornerstone for further adequate therapy planning. Therefore, clinical practice and research still focuses on diagnostic tools that can detect prostate cancer in early recurrence when it is undetectable in conventional diagnostic imaging. [sup.18] F-PSMA-1007 PET/CT is a novel method to evaluate patients with biochemical recurrent PCa. The aim of this review was to evaluate the role of [sup.18] F-PSMA-1007 PET/CT in prostate cancer local recurrence, lymph node metastases and bone metastases detection. Methods: Original studies, reviews and five meta-analyses were included in this article. A total of 70 studies were retrieved, 31 were included in the study. Results: All patients described in the studies underwent [sup.18] F-PSMA-1007 PET/CT. The administered [sup.18] F-PSMA-1007 individual dose ranged from 159 ± 31 MBq to 363.93 ± 69.40 MBq. Results showed that [sup.18] F-PSMA-1007 PET/CT demonstrates a good detection rate in recurrent prostate cancer. Conclusions: [sup.18] F-PSMA-1007 PET/CT appears to achieve reliable performance in detecting recurrent prostate cancer. The high detection rate of [sup.18] F-PSMA-1007 PET/CT in recurrent prostate cancer was confirmed, especially in local recurrence and small lymph nodes with non-specific characteristics on conventional diagnostic imaging methods. However, several authors emphasize some limitations for this tracer—for example, non-specific uptake in bone lesions that can mimic bone metastases.
ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics12123176