Magnetic Field Dependence of Spectral Correlations between [sup.31]P-Containing Metabolites in Brain

Spectral correlations between metabolites in [sup.31] P magnetic resonance spectroscopy (MRS) spectra of human brain were compared at 3 and 7 Tesla, the two commonly used magnetic field strengths for clinical research. It was found that at both field strengths, there are significant correlations bet...

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Bibliographic Details
Published inMetabolites Vol. 13; no. 2
Main Authors Hong, Sungtak, Shen, Jun
Format Journal Article
LanguageEnglish
Published MDPI AG 01.01.2023
Subjects
Brain
Chemical properties
Magnetic fields
Metabolites
Nuclear magnetic resonance spectroscopy
Phosphorus
Physiological aspects
Spectra
United States
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Summary:Spectral correlations between metabolites in [sup.31] P magnetic resonance spectroscopy (MRS) spectra of human brain were compared at 3 and 7 Tesla, the two commonly used magnetic field strengths for clinical research. It was found that at both field strengths, there are significant correlations between [sup.31] P-containing metabolites arising from spectral overlap, and their downfield correlations are markedly altered by the background spectral baseline. Overall, the spectral correlations between [sup.31] P-containing metabolites are markedly reduced at 7 Tesla with the increased chemical shift dispersion and the decreased membrane phospholipid signal. The findings provide the quantitative landscape of pre-existing correlations in [sup.31] P MRS spectra due to overlapping signals. Detailed procedures for quantifying the pre-existing correlations between [sup.31] P-containing metabolites are presented to facilitate incorporation of spectral correlations into statistical modeling in clinical correlation studies.
ISSN:2218-1989
2218-1989
DOI:10.3390/metabo13020211