Utilization of reaction for [sup.86]Zr production with medium energy protons and development of a [sup.86]Zr [right arrow] [sup.86]Y radionuclide generator

• Published in: Journal of radioanalytical and nuclear chemistry Vol. 316; no. 1; p. 191
• Main Authors: Baimukhanova, Ayagoz, Radchenko, Valery, Kozempel, Jan, Marinova, Atanaska, Brown, Victoria, Karandashev, Vasily, Karaivanov, Dimitr, Schaffer, Paul, Filosofov, Dmitry
• Format: Journal Article
• Language: English
• Published: Springer 01.04.2018
• Subjects: Positron emission tomography; Protons; Rare earth metal compounds; Rare earth metals
• ISSN: 0236-5731; 1588-2780
• DOI: 10.1007/s10967-018-5730-7

Utilization of (p, 4n) reaction channel for the production of medical radionuclides became very attractive with commercial availability of medium energy cyclotrons. Significantly higher yields and radionuclidic purity may open new perspectives for several novel and some of the radionuclides previously have not been considered due to production difficulties. In present work, we show the proof-of-principle study on the production of Y for Positron Emission Tomography imaging via radionuclide generator [sup.86]Zr [right arrow] [sup.86]Y. Production suitability of [sup.86]Zr from natural yttrium target and radiochemical separation strategies were tested. In addition, two generator systems were proposed and evaluated. Keywords Medium energy protons * Yttrium target * [sup.86]Zr [right arrow] [sup.86]Y generator * Ion exchange * ZR resin