Immune response to measles vaccine after mass vaccination in Urmia, Islamic Republic of Iran/Reponse immunitaire au vaccin antirougeoleux apres une vaccination de masse a Orumieh (Republique islamique d'Iran)

We investigated the effectiveness of the mass measles vaccination campaign in Urmia, Islamic Republic of Iran, by examining the measles IgG seroprevalence and antibody response from paired data before and after the campaign. The overall seropositive rate of 624 subjects aged 5-25 years increased 1 y...

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Bibliographic Details
Published inEastern Mediterranean health journal Vol. 15; no. 3; pp. 516 - 525
Main Authors Yekta, Z, Pourali, R, Taravati, M.R, Shahabi, S, Salary, S, Khalily, F, Farzin, A
Format Journal Article
LanguageEnglish
Published World Health Organization 01.05.2009
Subjects
Care and treatment
Causes of
Children
Diseases
Immune response
Measles
Measles vaccine
Physiological aspects
Prognosis
Iran
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ISSN1020-3397

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Summary:We investigated the effectiveness of the mass measles vaccination campaign in Urmia, Islamic Republic of Iran, by examining the measles IgG seroprevalence and antibody response from paired data before and after the campaign. The overall seropositive rate of 624 subjects aged 5-25 years increased 1 year after the mass vaccination (from 53.0% to 72.3%). A rise in antibody titre occurred in all age groups except the 21-25 years group, which had the highest titre before mass vaccination. On logistic regression analysis, only immune status prior to vaccination was significantly associated with the seroresponse. It may be cost-effective to check antibody titres before mass vaccinations, especially in high vaccine coverage regions with circulating wild virus. Nous avons etudie l'efficacite de la campagne de vaccination antirougeoleuse de masse a Orumieh (Republique islamique d'Iran) en examinant la seroprevalence des IgG anti-rougeole et la reponse en anticorps a partir de donnees appariees avant et apres la campagne. Le taux global de seropositivite de 624 sujets ages de 5 a 25 ans augmentait un an apres la vaccination de masse (il passait de 53,0 a 72,3 %). Une augmentation du titre d'anticorps etait observee dans tous les groupes d'ages, a l'exception des 21-25 ans, qui avaient le titre le plus eleve avant la vaccination de masse. Selon l'analyse de regression logistique, seul le statut immunitaire avant la vaccination etait significativement associe a la reponse serologique. Il peut s'averer economiquement efficace de verifier les titres d'anticorps avant les vaccinations de masse, notamment dans les regions ou la couverture vaccinale est elevee et ou le virus sauvage circule. [TEXT NOT REPRODUCIBLE IN ASCII]
ISSN:1020-3397