Effects of CRAP Treatment on Electroencephalographic Activity in Patients with Obstructive Sleep Apnea Syndrome During Deep Sleep with Consideration of Cyclic Alternating Pattern

• Published in: Nature and science of sleep Vol. 14; pp. 2075 - 2089
• Main Authors: Chen, Shuliang, Li, Qi, Zou, Xueliang, Zhong, Zhijun, Ouyang, Qian, Wang, Mengmeng, Luo, Yaxing, Yao, Dongyuan
• Format: Journal Article
• Language: English
• Published: Dove Medical Press Limited 30.11.2022
• Subjects: Care and treatment; Continuous positive airway pressure; Electroencephalography; Sleep apnea syndromes; China
• ISSN: 1179-1608; 1179-1608
• DOI: 10.2147/NSS.S382305

Objective: To investigate whether continuous positive airway pressure (CPAP) treatment would change EEG activities associated with cyclic alternating pattern (CAP subtype A1, A2, and A3) and non-CAP (NCAP) during non-rapid eye movement sleep stage 3 (N3) in patients with obstructive sleep apnea (OSA). Methods: The effects of CPAP treatment on the percentages of sleep stage N3 occupied by the CAP and NCAP, power of EEG waves in the CAP and NCAP were examined in 18 patients with moderate-to-severe OSA undergoing polysomnographic recordings. Results: Apnea and hypopnea index during sleep stage N3 was positively correlated with ratios of phases A2 and A3 duration to total phase A duration [Phase (A2+A3) /Phase A] and negatively correlated with phase A1/phase A. With CPAP treatment, percentages of sleep stage N3 occupied by total CAPs and subtypes A2 and A3, as well as CAP A2 and CAP A3 indexes were significantly decreased while percentages of sleep stage N3 occupied by NCAP (NCAP/N3) and CAP A1 index were significantly increased. In addition, CPAP treatment significantly decreased percentage of respiratory events associated CAPs and increased percentage of non-respiratory related CAPs. Moreover, absolute and relative delta power was significantly increased during phase A1, unchanged during phase A2 and phase B2, and significantly decreased during phases B1, A3 and B3. The absolute power of faster frequency EEG waves in CAPs showed a general trend of decrease. The absolute and relative power of delta waves with amplitudes [greater than or equal to]75 [micro]V, but not <75 [micro]V, was significantly increased. Conclusion: CPAP treatment improves the sleep quality in OSA patients mainly by increasing delta power and decreasing power of higher frequency waves during phase A1, and decreasing CAP A2 and A3 indexes as well as increasing NCAP/N3 and power of delta waves with amplitudes [greater than or equal to]75 [micro]V during NCAP. Keywords: obstructive sleep apnea, continuous positive airway pressure, polysomnographic recordings, non-rapid eye movement sleep, cyclic alternating pattern