Is quetiapine safe in overdose? A case report and literature review/Ketyapin doz asiminda guvenli mi? Olgu sunumu ve literaturun gozden gecirilmesi

• Published in: Noro-Psikiyatri Arsivi Vol. 49; no. 2; p. 157
• Main Authors: Tomruk, Nesrin Buket, Saatcioglu, Omer, Delice, Mehtap, Alpay, Nihat
• Format: Journal Article
• Language: English
• Published: Ankara AVES 01.06.2012; BAYT Ltd. Co
• Subjects: Bipolar disorder; Drugs; Overdose; Quetiapine; Schizophrenia
• ISSN: 1300-0667; 1309-4866
• DOI: 10.4274/npa.y5723

Quetiapine is an atypical antipsychotic medication used in the management of affective disorders and schizophrenia, in which suicide attempts are not infrequent. A favorable risk/benefit profile of quetiapine has been reported in the literature, but data on its overdose are only sparsely available. In this article, we present the case of a 25-year-old female patient with bipolar disorder to highlight the safety of quetiapine overdose. She had seven previous impulsive suicide attempts in mixed episodes. She was found unconscious after ingesting 9 grams of quetiapine. Recovery was obtained with supportive treatment. Quetiapine has greater safety in overdose than the traditional antipsychotic agents. With good supportive care, of overdose symptoms typically resolve within 24 hours and none of the side effects are irreversible. Quetiapine is an antipsychotic of choice in patients with risk of medication-based suicidal attempts. (Archives of Neuropsychiatry 2012;49:157-159! Keywords: Quetiapine, overdose, pharmacokinetics, coma, suicide Ketyapin, afektif bozukluk ve sizofrenide kullanilan ve intihar girisiminde kullanimi nadir olmayan bir atipik antipsikotikdir. Literaturde olumlu risk/yarar profili oldugu belirtilmis ise de doz asimina ait bilgi yetersizdir. Bu yazida, ketyapinin doz asiminda guvenilir oldugunu vurgulayan bir olgu sunulmustur. Bipolar bozuklugu olan 25 yasinda kadin hastanin karma edizodlarinda alti kez durtusel intihar girisimi vardi. Hasta, ketyapini 9 gram aldiktan sonra bilinci kapali olarak bulundu. Destek tedavisi ile duzelme saglandi. Ketyapinin asiri dozda geleneksel antipsikotik ilaclardan daha guvenli oldugu, iyi destek tedavisi ile 24 saatte duzelme saglandigi ve yan etkilerinin geri donusumlu oldugu tartisildi. Ketyapin ilacla intihar riski olan hastalarda uygun bir antipsikotiktir. (Noropsikiyatri Arsivi 2011;49: 157-159) Anahtar kelimeler: Ketyapin, asiri doz, farmakokinetik, koma, intihar