CYTOMORPHOMETRY OF BUCCAL SMEARS OF NICOTIANA TABACUM (NASWAR) USERS: A PILOT STUDY

• Published in: Pakistan oral & dental journal Vol. 34; no. 3
• Main Authors: Masood, Rabia, ROZINA, NADIA ZAIB, JAFFAR KHOLA, Khan, Ahmed, MUNNAZZA JAVED, Raza, Ali, Umer, Naila
• Format: Journal Article
• Language: English
• Published: Peshawar Knowledge Bylanes 30.09.2014; Pakistan Oral & Dental Journal
• Subjects: Biomarkers; Cytodiagnosis; Dental surgery; Health aspects; Medical examination; Methods; Oral mucosa; Sinuses; Tobacco (Plant)
• ISSN: 1012-8700; 1996-4439

The objective of the current study was to asses the cytomporphometric changes in buccal mucosal smears of naswar users. The study groups consisted of 24 subjects divided into two groups i.e A con- trol group and B naswar users of ages between 15yrs-60yrs. Cellular diameter CDnuclear diameter ND and nuclear to cytoplasmic ratio N/C ratio was assessed in buccal mucosal smears taken from clinically normal mucosa of naswar users and normal subjects using exfoliative cytology. The mean cellular diameter of goup A and B was 43.93m and 44.13m respectively.The mean nuclear diameter of control group and naswar users was 9.99m and 11.88m respectively.And the mean N/C ratio of group A and B was 1: 4.42 and 1: 3.71 respectively.The independent T test showed significant results (p = 0.000) for nuclear diameter ND and N/C ratio both. Cytomorphometric changes in cellular diameternuclear diameter and N/C ratio assessed by our study depict only cause effect relationship between naswar and and association of these changes with dysplasia or premamlignancy needs further verification with the help of specific immunomarkers.