The radioprotective effects of aqueous extract from chlorococcal freshwater algae (Chlorella kessleri) in mice and rats

In experiments on mice and rats the effect was studied of a single administration of aqueous extract from chlorococcal freshwater algae - Ivastimul - on their radiosensitivity. After injection of this substance the number of haemopoietic stem cells in the bone marrow and spleen of mice (CFUs) increa...

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Bibliographic Details
Published inStrahlentherapie und Onkologie Vol. 165; no. 11; p. 813
Main Authors Rotkovská, D, Vacek, A, Bartonícková, A
Format Journal Article
LanguageEnglish
Published Germany 01.11.1989
Subjects
Animals
Bone Marrow - immunology
Chlorella
Female
Hematopoietic Stem Cells - immunology
Injections, Intramuscular
Injections, Intraperitoneal
Injections, Subcutaneous
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Plant Extracts
Radiation Dosage
Radiation-Protective Agents - administration & dosage
Rats
Rats, Inbred Strains
Sodium Chloride
Spleen - immunology
Whole-Body Irradiation
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Summary:In experiments on mice and rats the effect was studied of a single administration of aqueous extract from chlorococcal freshwater algae - Ivastimul - on their radiosensitivity. After injection of this substance the number of haemopoietic stem cells in the bone marrow and spleen of mice (CFUs) increased, as did their survival after irradiation. Irradiation with a lethal dose of gamma rays 24 hours after the injection of Ivastimul is survived by a larger number of treated mice and rats than untreated ones. On the first day after the administration Ivastimul protects mice against brief and prolonged action of irradiation. The protective effect of Ivastimul was observed after intraperitoneal, intramuscular and subcutaneous administration.
ISSN:0179-7158