Nucleotide sensitivity of pancreatic ATP-sensitive potassium channels and type 2 diabetes

Type 2 diabetes is generally perceived as a polygenic disorder, with disease development being influenced by both hereditary and environmental factors. However, despite intensive investigations, little progress has been made in identifying the genes that impart susceptibility to the common late-onse...

Full description

Saved in:
Bibliographic Details
Published inDiabetes (New York, N.Y.) Vol. 51; no. 12; p. S358
Main Authors Schwanstecher, Christina, Schwanstecher, Mathias
Format Journal Article
LanguageEnglish
Published American Diabetes Association 01.12.2002
Subjects
Genetic aspects
Genetic polymorphisms
Health aspects
Potassium channels
Risk factors
Type 2 diabetes
Online AccessGet full text

Cover

More Information
Summary:Type 2 diabetes is generally perceived as a polygenic disorder, with disease development being influenced by both hereditary and environmental factors. However, despite intensive investigations, little progress has been made in identifying the genes that impart susceptibility to the common late-onset forms of the disease. E23K, a common single nucleotide polymorphism in [K.sub.IR]6.2, the pore-forming subunit of pancreatic [beta]-cell ATP-sensitive [K.sup.+] ([K.sub.ATP]) channels, significantly enhances the spontaneous open probability of these channels, and thus modulates sensitivities toward inhibitory and activatory adenine nucleotides. Based on previous association studies, we present evidence that with an estimated attributable proportion of 15% in Caucasians, E23K in [K.sub.IR]6.2 appears to be the most important genetic risk factor for type 2 diabetes yet identified.
ISSN:0012-1797
1939-327X