Association of elevated neural cell adhesion molecule with disease severity in bipolar disorder

The prevalence is bipolar disorder is increasing worldwide owing to its recurring nature and severity of episodes. Alteration in synaptic plasticity plays a key role in its pathogenesis. The present study was undertaken as there are neural cell adhesion molecule (NCAM) levels in bipolar disorders. T...

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Bibliographic Details
Published inIndian journal of clinical biochemistry Vol. 33; no. S1; p. S75
Main Authors Saravanan, K, Raj, Blessed, Nandeesha, H, Menon, Vikas
Format Journal Article
LanguageEnglish
Published Springer 24.05.2022
Subjects
Bipolar disorder
Comparative analysis
Medical research
Medicine, Experimental
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Summary:The prevalence is bipolar disorder is increasing worldwide owing to its recurring nature and severity of episodes. Alteration in synaptic plasticity plays a key role in its pathogenesis. The present study was undertaken as there are neural cell adhesion molecule (NCAM) levels in bipolar disorders. To assess NCAM levels and their association with disease severity in patients with bipolar disorder. 40 bipolar disorder cases and 40 age matched controls were enrolled in the study. NCAM levels were estimated in all the subjects. NCAM was significantly increased in patients with bipolar disorder compared to controls. Also NCAM was positively correlated with disease severity (p < 0.001) and duration of illness (p = 0.019) in the cases. We conclude that NCAM is increased and associated with disease severity in bipolar disorder.
ISSN:0970-1915