Microglial G.sub.i-dependent dynamics regulate brain network hyperexcitability

Microglial surveillance is a key feature of brain physiology and disease. Here, we found that G.sub.i-dependent microglial dynamics prevent neuronal network hyperexcitability. By generating Mg.sup.PTX mice to genetically inhibit G.sub.i in microglia, we show that sustained reduction of microglia bra...

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Published inNature neuroscience Vol. 24; no. 1; pp. 19 - 23
Main Authors Merlini, Mario, Rafalski, Victoria A, Ma, Keran, Kim, Keun-Young, Bushong, Eric A, Rios Coronado, Pamela E, Yan, Zhaoqi, Mendiola, Andrew S, Sozmen, Elif G, Ryu, Jae Kyu, Haberl, Matthias G, Sampson, Daniel Naranjo, Petersen, Mark A, Bardehle, Sophia, Tognatta, Reshmi, Dean, Terry, Jr, Acevedo, Rosa Meza, Cabriga, Belinda, Thomas, Reuben, Coughlin, Shaun R, Ellisman, Mark H, Palop, Jorge J, Akassoglou, Katerina
Format Journal Article
LanguageEnglish
Published Nature Publishing Group 01.01.2021
Subjects
Brain diseases
Development and progression
Health aspects
Neural circuitry
Physiological aspects
Seizures (Medicine)
United States
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Summary:Microglial surveillance is a key feature of brain physiology and disease. Here, we found that G.sub.i-dependent microglial dynamics prevent neuronal network hyperexcitability. By generating Mg.sup.PTX mice to genetically inhibit G.sub.i in microglia, we show that sustained reduction of microglia brain surveillance and directed process motility induced spontaneous seizures and increased hypersynchrony after physiologically evoked neuronal activity in awake adult mice. Thus, G.sub.i-dependent microglia dynamics may prevent hyperexcitability in neurological diseases.
ISSN:1097-6256
1546-1726
DOI:10.1038/s41593-020-00756-7