Omentin-1 And Il-6 Play Role In Inflammatory Mechanism Of Diabetic Nephropathy In Type 2 Diabetes Mellitus Patients

INTRODUCTION: Diabetic nephropathy (DN) is one of the major chronic vascular complication of T2DM and leading cause of end-stage renal disease. Inflammation is one of the proposed pathway which leads to microvascular complications in T2DM but exact mechanism is still unclear. Omentin-1 is an anti-in...

Full description

Saved in:
Bibliographic Details
Published inIndian journal of clinical biochemistry Vol. 32; no. S1; p. S113
Main Authors Yasir, Senthilkumar, G.P, Anithalekshmi, M.S, Parameswaran, S
Format Journal Article
LanguageEnglish
Published Springer 24.05.2022
Subjects
Adipose tissues
Analysis
Blood sugar
Chronic kidney failure
Diabetic nephropathies
Inflammation
Insulin
Insulin resistance
Medical research
Medicine, Experimental
Type 2 diabetes
Online AccessGet full text

Cover

More Information
Summary:INTRODUCTION: Diabetic nephropathy (DN) is one of the major chronic vascular complication of T2DM and leading cause of end-stage renal disease. Inflammation is one of the proposed pathway which leads to microvascular complications in T2DM but exact mechanism is still unclear. Omentin-1 is an anti-inflammatory adipokine, predominantly expressed in stromal vascular cells of visceral adipose tissue. It promotes insulin signaling. IL-6 is a multifunctional cytokine having role in immune and inflammatory responses. The present study was conducted to elucidate the role of omentin-1 and IL-6 in the pathogenesis of DN and its association with insulin resistance. We aimed to assess and compare the serum levels of omentin-1 and IL-6 in T2DM patients with and without DN. MATERIAL AND METHODS: Our study comprised of 2 groups of 41 each. Group A (controls) included T2DM without nephropathy patients and group B (cases) included T2DM nephropathy patients. Parameters studied were serum omentin-1, insulin, IL-6, fasting blood glucose, urea, creatinine, lipid profile, HOMAIR, eGFR and BMI. RESULTS: Omentin-1 (p=0.03) was significantly decreased; Concomitantly, significant increase in levels of insulin (p=0.004), IL-6 (p=0.023) and HOMA-IR (p=0.0004) were found in cases compared to controls. Bivariate analysis showed eGFR correlating positively with omentin-1 and negatively with insulin and IL-6 in the study population. CONCLUSION: Our study suggests omentin-1 and IL-6 having important role in pathogenesis of diabetic nephropathy, through inflammatory mechanism and insulin resistance, in type 2 diabetes mellitus patients. KEY WORDS: Diabetic nephropathy; Omentin-1; IL-6; Insulin resistance; Inflammation
ISSN:0970-1915
0974-0422