EVALUATION OF OXIDATIVE STRESS IN OBESE MEDICAL STUDENTS WITH REFERENCE TO CARDIOMETABOLIC SYNDROME

Background: The prevalence of obesity in young population is on rise. The major complication of obesity is dylipedemia, impaired glucose metabolism etc. It has been demonstrated that fat accumulation correlates with markers of systemic oxidative stress. Oxidative stress may have proinflammatory role...

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Bibliographic Details
Published inIndian journal of clinical biochemistry Vol. 27; no. S1; p. S85
Main Authors Padwal, Meghana K, Kamthe, Priya, Melinkeri, R.R
Format Journal Article
LanguageEnglish
Published Springer 24.05.2022
Subjects
Analysis
Atherosclerosis
Blood sugar
Glucose metabolism
Low density lipoproteins
Medical colleges
Medical students
Obesity in adolescence
Oxidative stress
Physiological aspects
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Summary:Background: The prevalence of obesity in young population is on rise. The major complication of obesity is dylipedemia, impaired glucose metabolism etc. It has been demonstrated that fat accumulation correlates with markers of systemic oxidative stress. Oxidative stress may have proinflammatory role on promoting atherosclerosis. Objectives: The present study was designed to evaluate the relationship between the marker oxidative stress i.e. Malondialdehyde (MDA) with reference to markers of Cardiometabolic Syndrome i.e. hs- CRP, lipid profile and blood glucose in healthy obese students. Material and Methods: The present study was a prospective case control study, carried out in a university medical college. The participants were healthy medical students of both the genders. They were divided into cases: Obese (BMI [greater than or equal to] 25 kg/m2; n=30) and controls: Non obese (BMI [less than or equal to] 25 kg/m2; n=30). Estimation of MDA, Lipid Profile, glucose levels were done by automated biochemistry analyser. Estimation of hs-CRP was done by automated chemiluminescence immunoassay system. Results: There was statistically significant rise in the levels of hs-CRP and MDA in obese students as compared to non obese (p=0.001). There was no statistically significant difference in the levels of blood glucose in both the groups (p = 0.06). However the levels of Total cholesterol, LDL were significantly increased in cases (p = 0.01), while levels of HDL were significantly decreased (p = 0.01) as compare to controls. Conclusions: There is increased oxidative stress in obesity which may aggrevate the proinflammatory processes of atherosclerosis. The metabolic changes in obesity are associated with to chronic systemic low grade inflammation. Keywords: Oxidative stress, Cardiometabolic Syndrome, MDA, hs--CRP.
ISSN:0970-1915
0974-0422