Evaluation of Activity of Serum Creatine Kinase and Lactate Dehydrogenase in Hypothyroid Patients

• Published in: Indian journal of clinical biochemistry Vol. 36; no. S1; p. S145
• Main Authors: Visen, Shilpa, Kaur, Jaskiran, Chauhan, Pratibha
• Format: Journal Article
• Language: English
• Published: Springer 24.05.2022
• Subjects: Comparative analysis; Creatine kinase; Hypothyroidism; Thyroid hormones
• ISSN: 0970-1915; 0974-0422

OBJECTIVES : To estimate serum creatine kinase and serum lactate dehydrogenase in hypothyroid patients and compare it with controls. METHODOLOGY : A cross-sectional study was conducted in department of Biochemistry & Endocrinology at SMS Medical College, Jaipur. Serum CK and serum LDH were measured in 50 patients with known history of hypothyroidism and the results were compared with the 50 age and sex matched controls. RESULTS-.Mean age in our study is 36.24 [+ or -] 10.87 years in cases vs 33.34 [+ or -] 9.92 years in controls. Mean serum creatine kinase in hypothyroid patients was 267.94 [+ or -] 129.60 U/L and in controls was 74.08 [+ or -] 30.46 U/L whereas mean LDH inpatients was 479.96 [+ or -] 150.41 U/L and in controls was 287.96 [+ or -] 70.35 U/L, which were statistically significant (P<0.05). Thus we can say serum CK and serum LDH are significantly increased in patients with hypothyroidism as compared to the control group. CONCLUSION : Significant increase in creatine kinase and lactate dehydrogenase activity shows muscular involvement occurs in hypothyroidism. Hence, these parameters can be used for screening of hypothyroidism and for diagnosing musculoskeletal involvement in hypothyroid patients. Keywords : Hypothyroidism, Thyroid hormone, Creatine Kinase, Lactate Dehydrogenase