[K.sup.+]-ATPase Activation by cAMP in the Midgut of Lutzomyia longipalpis

Lutzomyia longipalpis (Lutz & Neiva, 1912) females have been intensively studied regarding the regulation of midgut pH. The mechanisms involved in pH regulation are complex, and some aspects remain to be clarified. Here, we investigated the role of the [Na.sup.+]/[K.sup.+]-ATPase pump as an elec...

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Bibliographic Details
Published inJournal of insect science (Tucson, Ariz.) Vol. 22; no. 2
Main Authors Nepomuceno, Denise Barguil, Pessoa, Grasielle Caldas DAvila, Araujo, Ricardo Nascimento, Koerich, Leonardo Barbosa, Sant'Anna, Mauricio Roberto Viana, Pereira, Marcos Horacio, Gontijo, Nelder Figueiredo
Format Journal Article
LanguageEnglish
Published Oxford University Press 01.03.2022
Subjects
Adenosine triphosphatase
Cyclic adenylic acid
Digestive organs
Diptera
Physiological aspects
Brazil
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Summary:Lutzomyia longipalpis (Lutz & Neiva, 1912) females have been intensively studied regarding the regulation of midgut pH. The mechanisms involved in pH regulation are complex, and some aspects remain to be clarified. Here, we investigated the role of the [Na.sup.+]/[K.sup.+]-ATPase pump as an electrochemical potential generator and its modulation by the second messenger cAMP in the midgut of female L. longipalpis. Our results suggest that not only may [Na.sup.+]/[K.sup.+]-ATPase be the main generator of an electrochemical potential across membranes in the midgut of female L. longipalpis, but also its activity is positively regulated by cAMP cAMP-mediated [Na.sup.+]/[K.sup.+]-ATPase pump activity might be necessary to maintain the transport of the nutrients produced during blood digestion.
ISSN:1536-2442
1536-2442
DOI:10.1093/jisesa/ieac008