Identification and Molecular Characterization of Polymorphism in Type 2 Dopamine Receptor and CYP2D6 Gene Polymorphisms in North Indian Schizophrenic Population--A Multicentric Study

Schizophrenia is a severe psychiatric disorder characterized by psychotic symptoms i.e. delusions, hallucinations, disturbances of thought, disorganized speech & behavior causing significant impairment in social and occupational functioning. Schizophrenia is associated with unknown etiology, com...

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Published inIndian journal of clinical biochemistry Vol. 30; no. S1; p. S32
Main Authors Gupta, Deepti, Kaur, Gurjit, Chavan, B.S, Tripathi, Adarsh, Gupta, Rajiv, Gargi, Parshotam Dass, Prasad, Rajendra, Gautam, Shiv Kumar
Format Journal Article
LanguageEnglish
Published Springer 24.05.2022
Subjects
Analysis
Cardiac glycosides
Cardiotonic agents
Cytochrome P-450
Development and progression
Dopamine receptors
Genes
Genetic aspects
Genetic polymorphisms
Genetic research
Medical research
Medicine, Experimental
Phenols
Schizophrenia
Serotonin
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Summary:Schizophrenia is a severe psychiatric disorder characterized by psychotic symptoms i.e. delusions, hallucinations, disturbances of thought, disorganized speech & behavior causing significant impairment in social and occupational functioning. Schizophrenia is associated with unknown etiology, complex pathophysiology, long lasting and poor treatment outcome. Worldwide prevalence of schizophrenia is about 1% in general population. The mode of inheritance of schizophrenia is complex as it is a multifactorial psychiatric disorder in which both genetic factors and environmental interactions are involved. Moreover there are few reports available on polymorphism studies on dopamine receptors, serotonin receptors and CYP2D6 genes in schizophrenia patients in India.
ISSN:0970-1915
0974-0422