Association of Vitamin D with CRP Levels in Patients with Prostate Cancer

Prostate cancer is implicated as an important cause of morbidity and mortality in men worldwide. Inflammation plays a significant role in cancer. CRP is a well-known inflammatory marker and role of vitamin D in regressing inflammation and its anti-cancerous effect has long been known. Hence, we soug...

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Bibliographic Details
Published inIndian journal of clinical biochemistry Vol. 34; no. S1; p. S99
Main Authors Taneja, Kanchan, Sharma, Shikha, Patel, Seema
Format Journal Article
LanguageEnglish
Published Springer 24.05.2022
Subjects
Alfacalcidol
Calcifediol
Cancer patients
Care and treatment
Development and progression
Health aspects
Inflammation
Mortality
Prostate cancer
Vitamin D
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Summary:Prostate cancer is implicated as an important cause of morbidity and mortality in men worldwide. Inflammation plays a significant role in cancer. CRP is a well-known inflammatory marker and role of vitamin D in regressing inflammation and its anti-cancerous effect has long been known. Hence, we sought to study the association of vitamin D levels with CRP levels in prostate cancer patients. The study was conducted in Department of biochemistry in association with Department of urology, VMMC and SJH, New Delhi. The case control study included forty newly diagnosed cases of prostate cancer histologically confirmed by trans rectal needle biopsy with elevated PSA level>4ng/ml and forty age matched healthy control. Vitamin D, CRP and PSA levels were estimated and its association seen. Vitamin D was significantly low (p<0.05) and CRP significantly high (p<0.001) in prostate cancer patients compared to control. A significant negative association was observed between Vitamin D and CRP in cancer patients (3=0.0004) which was not there in case of controls (p=0.4418). Moreover a significant negative association of Vitamin D with PSA (0.0042) and positive association of CRP with PSA (3<0.0001) was also seen. A marked increase in CRP and decrease in vitamin D supports the inflammatory etiology of Prostate cancer. It has been known that vitamin D receptors and enzymes are also expressed in human prostate epithelial cells and vitamin D has potential immunomodulatory role in reducing inflammation which could be the possible reason of a strong negative association with CRP levels as we observe in our study. Therefore it can be suggested that therapeutic supplementation of vitamin D can be recommended for chemo prevention since it can be easily supplemented as vitamins and fortified foods.
ISSN:0970-1915
0974-0422