Study on Role of DCP in HCC among South Indian Population

Background: Hepatocellular carcinoma (HCC) is the primary and most common malignant tumor of liver and it is considered as the fifth most common cancer worldwide. As per the data available, the incidence of HCC in India is 1.6% per year The prevalence of India varies from 0.2 to 1.6%. Several resear...

Full description

Saved in:
Bibliographic Details
Published inIndian journal of clinical biochemistry Vol. 36; no. S1; p. S73
Main Author Sundaresan, S
Format Journal Article
LanguageEnglish
Published Springer 24.05.2022
Subjects
Enzyme-linked immunosorbent assay
Liver cancer
Liver cirrhosis
Medical research
Medicine, Experimental
Online AccessGet full text

Cover

More Information
Summary:Background: Hepatocellular carcinoma (HCC) is the primary and most common malignant tumor of liver and it is considered as the fifth most common cancer worldwide. As per the data available, the incidence of HCC in India is 1.6% per year The prevalence of India varies from 0.2 to 1.6%. Several researchers were keen to assess the role of novel tumor markers in blood and body fluids for their clinical ability to diagnose HCC at the earliest. Objectives: The aim of this study is to determine the role of tumour markers in hepatocellular carcinoma individuals and the risk factors associated with HCC. Methodology: A total of 210 HCC individuals from the Hepatology Unit, Gleneagles Global Health City, Chennai, were enrolled in this study. Patients with HCC were clinically diagnosed according to clinical examination, radiological investigation [US/CT] and laboratory investigations. Additionally, 30 cirrhotic individuals and 30 healthy subjects were included as a comparative group.. Results: The tumor marker DCP were determined by ELISA method using the G-Biosciences ELISAkit (G-Biosciences, USA) according to the manufacturers' protocol. Serum samples from HCC individuals, cirrhotic cases and healthy individuals were used for tumor markers determination and the results were analyzed using Bio-Rad analyser. Results showed that DCP had the sensitivity of 81.0% and specificity of 88.4% with 95% Cl. The criterion value for the marker was [less than or equal to] 56.96 ng/mL. The Youden index value was 0.7. Conclusion: We found that the tumor markers DCP showed better sensitivity and specificity when compared with the existing marker AFP. Keywords: HCC, DCP, LIVER, CANCER
ISSN:0970-1915