Serum Trace Elements and their Association with Type 2 Diabetes Mellitus

Insulin action on reducing blood glucose can be enhanced by some race elements such as chromium, magnesium, zinc, manganese, and selenium. It is also reported that the metabolism of several trace elements alters type 2 diabetes mellitus (T2DM) and these elements might have specific roles in the path...

Full description

Saved in:
Bibliographic Details
Published inIndian journal of clinical biochemistry Vol. 34; no. S1; p. S212
Main Author Prasad, D.K.V
Format Journal Article
LanguageEnglish
Published Springer 24.05.2022
Subjects
Analysis
Blood sugar
Physiological aspects
Selenium
Type 2 diabetes
Zinc in the body
Online AccessGet full text

Cover

More Information
Summary:Insulin action on reducing blood glucose can be enhanced by some race elements such as chromium, magnesium, zinc, manganese, and selenium. It is also reported that the metabolism of several trace elements alters type 2 diabetes mellitus (T2DM) and these elements might have specific roles in the pathogenesis and progress of diabetes. However, it is unclear whether DM and hyperglycemia affect trace element status or DM sets in due to the deficiency of trace elements. The aim of the present study was to evaluate in changes in trace elements such as copper, zinc, magnesium, selenium and chromium in type 2 diabetes mellitus patients (T2DM) and their correlation with metabolic parameters such as duration of diabetes, BMI, HbA1c, triglycerides, HDL and LDL. One hundred subjects with T2DM and equal number of age and sex matched controls were also included for the study. Trace elements were studied using inductively coupled plasma mass spectrometry (ICP-MS). Correlation analyses of trace elements with metabolic parameters were analyzed using Pearson correlation coefficient. Significantly higher levels of FBS, HbA1c, BMI and triglycerides whereas significantly lower levels of serum Zn, Se, Cr, and Fe were found in T2DM as compared to controls (p<0.05). A positive correlation was noticed between Cu and duration of the diabetes (p<0.05). Similarly Zn also showed a positive correlation with HbA1c (<0.05) whereas negative correlation was found between Se and FBS, HDL cholesterol (<0.05). In addition, highly significant negative correlation was observed between serum Mg and HbA1c (p<0.05). Significantly lower levels of Zn, Mg, Cr, Se, Fe and higher levels of Cu in the present study signifies their association with T2DM. Lower Mg and Zn levels have been linked to poor glycemic control in T2DM; therefore, screening for Mg and Zn deficiency should be corrected in T2DM patients along with oral antihyperglycemic agents.
ISSN:0970-1915