Study on Liver Function In Pregnant Anemic Women Upon Iron and Folic Acid Therapy

INTRODUCTION: Oral iron therapy is the most widely prescribed treatment for iron deficiency anemia. However, oral iron supplementation may also lead to various health problems. The recognition of these physiological variations is essential for the diagnosis of liver diseases during the course of pre...

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Published inIndian journal of clinical biochemistry Vol. 32; no. S1; p. S86
Main Authors Tiwari, Amit Kumar Mani, Mahdi, Abbas Ali, Mishra, Sanjay
Format Journal Article
LanguageEnglish
Published Springer 24.05.2022
Subjects
Aspartate
Bilirubin
Care and treatment
Folic acid
Hemoglobin
Iron deficiency anemia
Liver
Liver diseases
Phosphatases
Physiological aspects
Pregnancy
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Summary:INTRODUCTION: Oral iron therapy is the most widely prescribed treatment for iron deficiency anemia. However, oral iron supplementation may also lead to various health problems. The recognition of these physiological variations is essential for the diagnosis of liver diseases during the course of pregnancy. Therefore, the objective of this study was to assess the variations in levels of routine LFTs before and after iron and folic acid treatment. MATERIALS AND METHODS: Iron and folic acid supplementation was given to 500 anemic women (mild=200, moderate=200, and severe=100) and 100 age matched non-anemic controls daily for 100 days. Blood index values and liver function parameters were estimated as per standard protocols. RESULTS: Blood index values and liver function parameters were estimated as per standard protocols. Hemoglobin (Hb) and total protein (TP), iron (Fe), albumin and alkaline phosphatase (ALP) levels were found significantly increased (P<0.001; p<0.01; p<0.05) in anemic and control subjects after treatment. Lipid peroxidation (LPx), aspartate transaminase (AST) and alanine transaminase (ALT) were increased in pre-treated groups and further increased after treatment. Moreover, gamma-glutamyl transpeptidase (GGT) was found to be decreased before even after iron and folic acid supplementation in all subjects. CONCLUSION: Treatment with iron and folic acid although has good efficacy for Hb and body iron stores but for the cost of increasing the associated compartment of total bilirubin, AST, ALT and GGT levels. Authors suggested that liver function tests monitored at regular intervals during pregnancy. KEY WORDS: Pregnancy, Iron deficiency anemia, Iron supplementation, liver function.
ISSN:0970-1915