The complex interplay between hormones and bone minerals in Beta thalassemia major pediatric patients

Beta Thalassemia major affects over 1 lac people and over 8000 reported thalassemic births take place every year in India. Regular blood transfusions and chelation therapy have considerably prolonged survival in thalassemic patients. Despite a significant increase in the lifespan of these patients,...

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Bibliographic Details
Published inIndian journal of clinical biochemistry Vol. 33; no. S1; p. S32
Main Authors Uppal, Vibha, Aggarwal, Vijay Kumar, Choudhary, Sanjay
Format Journal Article
LanguageEnglish
Published Springer 24.05.2022
Subjects
Alfacalcidol
Blood transfusion
Calcifediol
Care and treatment
Children
Ferritin
Health aspects
Hypothyroidism
Parathyroid hormone
Pediatrics
Phosphatases
Thalassemia
Vitamin D
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Summary:Beta Thalassemia major affects over 1 lac people and over 8000 reported thalassemic births take place every year in India. Regular blood transfusions and chelation therapy have considerably prolonged survival in thalassemic patients. Despite a significant increase in the lifespan of these patients, many endocrine abnormalities such as hypogonadism, diabetes mellitus, hypothyroidism and Hyperparathyroidism develop due to an iron overload. The paucity of data in Indian population regarding the Vitamin D level and Parathyroid hormone levels in Beta-Thalassemia children prompted us to study the complex interplay of various parameters including Vitamin D, Parathyroid hormone (PTH), Ferritin, Calcium, Alkaline Phosphatase (ALP) and Phosphorous levels in these children. A Prospective case control study was planned. Sixty Beta Thalassemia children (cases) and an equal number of age and sex matched apparently healthy children acted as controls were included in the study. All blood samples were tested for their respective Vitamin D levels & Serum Parathyroid levels along with Ferritin, Calcium Alkaline Phosphatase and Phosphorus and were compared against their age specific normal measurements. Vitamin D levels were significantly deficient (66.67%) in thalassemic patients than in controls (P value < 0.0001). There was no significant difference in the serum PTH levels in cases and controls. Vitamin D deficiency is prevalent in most part of our country but it is far more severe in children affected by thalassemia. Parathyroid hormones alteration is not significantly seen in early life.
ISSN:0970-1915
0974-0422